Article
DGK and DZHK position paper on genome editing: basic science applications and future perspective.
Basic research in cardiology - 15 Jan 2021
Brandes Ralf P, Dueck Anne, Engelhardt Stefan, Kaulich Manuel, Kupatt Christian, De Angelis Maria Teresa, Leisegang Matthias S, le Noble Ferdinand, Moretti Alessandra, Müller Oliver J, Skryabin Boris V, Thum Thomas, Wurst Wolfgang
Abstract excerpt
For a long time, gene editing had been a scientific concept, which was limited to a few applications. With recent developments, following the discovery of TALEN zinc-finger endonucleases and in particular the CRISPR/Cas system, gene editing has become a technique applicable in most laboratories. The current gain- and loss-of function models in basic science are revolutionary as they allow unbiased screens of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.