CRISPR/Cas9 Genome Editing as a Strategy to Study the Tumor Microenvironment in Transgenic Mice.

doi:10.1007/978-1-4939-3801-8_19

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Article

CRISPR/Cas9 Genome Editing as a Strategy to Study the Tumor Microenvironment in Transgenic Mice.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Yamanaka Yojiro

Abstract excerpt

Development of engineered site-specific endonucleases like zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9 has been revolutionizing genetic approaches in biomedical research fields. These new tools have opened opportunities to carry out targ...

Topics

Animals
CRISPR-Cas Systems
DNA Breaks, Double-Stranded
DNA Repair
Disease Models, Animal
Gene Editing
Genotype
Mice
Mice, Transgenic
Neoplasms
RNA, Guide, CRISPR-Cas Systems
Tumor Microenvironment

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