Article
Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease.
Folia neuropathologica - 1 Jan 2019
García Silvia, López-Hernández Luz, Dávila-Maldonado Luis, Cuevas-García Carlos, Gallegos-Arreola Martha, Alcaraz-Estrada Sofía, Cortes-Espinosa Leticia, Flores Carlos, Canto Patricia, Vázquez Ramón
Abstract excerpt
INTRODUCTION: Sporadic Parkinson's disease (PD) is a neurodegenerative disorder of unknown etiology. In recent years, it has been established that a genetic component underlies different forms of the disease. For instance, mitochondrial genome variants have been implicated in the pathogenesis of the PD. AIM OF THE STUDY: To determine the association of tRNA(Gln) 4336 and 8701A>G (ATP6: Thr59Ala) mitochondrial DNA...
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