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Article

TGM6 variants in Parkinson's disease: clinical findings and functional evidence.

Journal of integrative neuroscience - 30 Mar 2020

Chen Kui, Lu You, Peng Fang, Yu Hui-Ling, Wu Jia-Yan, Tan Yan, Zhao Yan-Xin

Abstract excerpt

TGM6 encodes transglutaminase 6, which catalyzes the covalent crosslinking of proteins through transamination reactions. Variants in TGM6 have been identified as the cause of spinocerebellar ataxia type 35. However, we found 12 TGM6 variants of low frequency among 308 patients with Parkinson's disease using next-generation sequencing technologies and multiple ligation-dependent probe amplification, including two...

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Identifiers

PMID: 32259886
DOI: 10.31083/j.jin.2020.01.1203

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