Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era.

Nutrients - 25 May 2017

Steluti Josiane, Carvalho Aline M, Carioca Antonio A F, Miranda Andreia, Gattás Gilka J F, Fisberg Regina M, Marchioni Dirce M

Abstract excerpt

Folate and other B vitamins are essential co-factors of one-carbon metabolism, and genetic variants, such as polymorphisms, can alter the metabolism. Furthermore, the adoption of food fortification with folic acid showed a decrease of homocysteine concentration. The aim of this study was to investigate the frequencies of the polymorphisms of enzymes and carrier proteins involved in one-carbon metabolism, and to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferredoxin-NADP Reductase

Share to Folic Acid

Share to Homocysteine

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

Share to Replication Protein C

Source

Open in PubMed Open full text

Identifiers

PMID: 28587068
DOI: 10.3390/nu9060539
PMCID: PMC5490518

Genes

MTHFR
MTRR
DHFR
MTR
RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era.PMID 28587068Read ↗

Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism.Semantic proximity Read ↗

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism.Semantic proximity Read ↗

Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular RisksSemantic proximity Read ↗

Association of genetic and epigenetic variants in one-carbon metabolism gene with folate treatment response in hyperhomocysteinaemia.Semantic proximity Read ↗

Associations between Genetic Variants and Blood Biomarkers of One-Carbon Metabolism in Postmenopausal Women from the Women's Health Initiative Observational Study.Semantic proximity Read ↗

Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.Semantic proximity Read ↗

Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with MTHFR Methylation LevelsSemantic proximity Read ↗

Genetic polymorphisms and folate status.Semantic proximity Read ↗

Single Nucleotide Polymorphisms in Key One-Carbon Metabolism Genes and Their Association with Blood Folate and Homocysteine Levels in a Chinese Population in Yunnan.Semantic proximity Read ↗

The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.