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Article

Human Cumulus Cells Molecular Signature in Relation to Oocyte Nuclear Maturity Stage

7 Nov 2011

Abstract excerpt

The bi-directional communication between the oocyte and the surrounding cumulus cells (CCs) is crucial for the acquisition of oocyte competence. We investigated the transcriptomic profile of human CCs isolated from mature and immature oocytes under stimulated cycle. We used human Genome U133 Plus 2.0 microarrays to perform an extensive analysis of the genes expressed in human CCs obtained from patients undergoing...

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PMID: 22087263
DOI: 10.1371/journal.pone.0027179

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