Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.

doi:10.1038/nm.2580

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Article

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.

Nature medicine - 20 Nov 2011

Robinson Dan R, Kalyana-Sundaram Shanker, Wu Yi-Mi, Shankar Sunita, Cao Xuhong, Ateeq Bushra, Asangani Irfan A, Iyer Matthew, Maher Christopher A, Grasso Catherine S, Lonigro Robert J, Quist Michael, Siddiqui Javed, Mehra Rohit, Jing Xiaojun, Giordano Thomas J, Sabel Michael S, Kleer Celina G, Palanisamy Nallasivam, Natrajan Rachael, Lambros Maryou B, Reis-Filho Jorge S, Kumar-Sinha Chandan, Chinnaiyan Arul M

Abstract excerpt

Breast cancer is a heterogeneous disease that has a wide range of molecular aberrations and clinical outcomes. Here we used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes...

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Identifiers

PMID: 22101766
DOI: 10.1038/nm.2580
PMCID: PMC3233654

Genes

MAST1
MAST2

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