A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers.

doi:10.1038/ncomms12222

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Article

A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers.

Nature communications - 13 Jul 2016

Ferrari Anthony, Vincent-Salomon Anne, Pivot Xavier, Sertier Anne-Sophie, Thomas Emilie, Tonon Laurie, Boyault Sandrine, Mulugeta Eskeatnaf, Treilleux Isabelle, MacGrogan Gaëtan, Arnould Laurent, Kielbassa Janice, Le Texier Vincent, Blanché Hélène, Deleuze Jean-François, Jacquemier Jocelyne, Mathieu Marie-Christine, Penault-Llorca Frédérique, Bibeau Frédéric, Mariani Odette, Mannina Cécile, Pierga Jean-Yves, Trédan Olivier, Bachelot Thomas, Bonnefoi Hervé, Romieu Gilles, Fumoleau Pierre, Delaloge Suzette, Rios Maria, Ferrero Jean-Marc, Tarpin Carole, Bouteille Catherine, Calvo Fabien, Gut Ivo Glynne, Gut Marta, Martin Sancha, Nik-Zainal Serena, Stratton Michael R, Pauporté Iris, Saintigny Pierre, Birnbaum Daniel, Viari Alain, Thomas Gilles

Abstract excerpt

HER2-positive breast cancer has long proven to be a clinically distinct class of breast cancers for which several targeted therapies are now available. However, resistance to the treatment associated with specific gene expressions or mutations has been observed, revealing the underlying diversity of these cancers. Therefore, understanding the full extent of the HER2-positive disease heterogeneity still remains...

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Identifiers

PMID: 27406316
DOI: 10.1038/ncomms12222
PMCID: PMC4947184

Genes

ERBB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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