Article
High Level Antibody Response to Pandemic Influenza H1N1/09 Virus Is Associated With Interferon-Induced Transmembrane Protein-3 rs12252-CC in Young Adults.
Frontiers in cellular and infection microbiology - 1 Jan 2018
Qin Ling, Wang Dayan, Li Dongfu, Zhao Yan, Peng Yanchun, Wellington Dannielle, Dai Yanchao, Sun Huanqin, Sun Jinping, Liu Guihai, McMichael Andrew, Dong Tao, Zhang Yonghong
Abstract excerpt
Background: The C allele of the interferon-induced transmembrane protein-3 (IFITM3) SNP rs12252, a common allele in South East Asia and China, is strongly associated with severe influenza infection. However, despite the high occurrence of rs12252-CC genotype in Chinese population (~25%), severe influenza infection is rare. The aim of study is to determine whether rs12252-CC individuals have pre-existing antibody...
Read the complete abstract on PubMed