Article
Rapid detection of Mycobacterium tuberculosis DNA and genetic markers for Isoniazid resistance in Ziehl-Neelsen stained slides.
Memorias do Instituto Oswaldo Cruz - 1 Jan 2020
Bello Graziele Lima, Morais Franciele Costa Leite, de Jesus Sheile Pinheiro, Wolf Jonas Michel, Gehlen Mirela, de Almeida Isabela Neves, Figueiredo Lida Jouca de Assis, Soares Tainá Dos Santos, Barcellos Regina Bones, Dalla Costa Elis Regina, de Miranda Silvana Spíndola, Rossetti Maria Lucia Rosa
Abstract excerpt
BACKGROUND: Early diagnosis of tuberculosis (TB) and identification of strains of Mycobacterium tuberculosis resistant to anti-TB drugs are considered the main factors for disease control. OBJECTIVES: To standardise a real-time polymerase chain reaction (qPCR) assay technique and apply it to identify mutations involved in M. tuberculosis resistance to Isoniazid (INH) directly in Ziehl-Neelsen (ZN) stained slides....
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