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Article

Diminished Cone Sensitivity in cpfl3 Mice Is Caused by Defective Transducin Signaling.

Investigative ophthalmology & visual science - 9 Apr 2020

Chen Natalie S, Ingram Norianne T, Frederiksen Rikard, Sampath Alapakkam P, Chen Jeannie, Fain Gordon L

Abstract excerpt

Purpose: Cone photoreceptor function loss 3 (Gnat2cpfl3/cpfl3 or cpfl3) is a mouse model commonly used as a functional cones null from a naturally occurring mutation in the α-subunit of cone transducin (Gnat2). We nevertheless detected robust cone-mediated light responses from cpfl3 animals, which we now explore. Methods: Recordings were made from whole retina and from identified cones with whole-cell patch clamp...

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Identifiers

PMID: 32315379
DOI: 10.1167/iovs.61.4.26
PMCID: PMC7401474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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