Article
Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2.
Investigative ophthalmology & visual science - 1 Nov 2006
Chang Bo, Dacey Mark S, Hawes Norm L, Hitchcock Peter F, Milam Ann H, Atmaca-Sonmez Pelin, Nusinowitz Steven, Heckenlively John R
Abstract excerpt
PURPOSE: To report a novel mouse model of achromatopsia with a cpfl3 mutation found in the ALS/LtJ strain. METHODS: The effects of a cpfl3 mutation were documented using fundus photography, electroretinography (ERG), and histopathology. Genetic analysis was performed using linkage studies and PCR gene identification. RESULTS: Homozygous cpfl3 mice had poor cone-mediated responses on ERG at 3 weeks that became...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.