Article
The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients.
Oncoimmunology - 1 Jan 2020
Margaroli Camilla, Cardenas Maria A, Jansen Caroline S, Moon Reyes Adriana, Hosseinzadeh Fares, Hong Gordon, Zhang Yilin, Kissick Haydn, Tirouvanziam Rabindra, Master Viraj A
Abstract excerpt
Infiltrating tumor neutrophils and myeloid-derived suppressor cells represent major populations in the tumor microenvironment that contribute to tumor progression. However, the phenotype of circulating and tumor-associated neutrophils, and the impact of cancer patients' metabolic state on neutrophil function need further characterization. Here we show that in kidney cancer patients, circulating neutrophils...
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