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N1 versus N2 and PMN-MDSC: A critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncology.

Immunological reviews - 1 Mar 2023

Antuamwine Benedict Boateng, Bosnjakovic Rebeka, Hofmann-Vega Francisca, Wang Xi, Theodosiou Theodosios, Iliopoulos Ioannis, Brandau Sven

Abstract excerpt

Research on tumor-associated neutrophils (TAN) currently surges because of the well-documented strong clinical relevance of tumor-infiltrating neutrophils. This relevance is illustrated by strong correlations between high frequencies of intratumoral neutrophils and poor outcome in the majority of human cancers. Recent high-dimensional analysis of murine neutrophils provides evidence for unexpected plasticity of...

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PMID: 36504274
DOI: 10.1111/imr.13176

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