Article
The invasive margin of early-stage human colon tumors is infiltrated with neutrophils of an antitumoral phenotype.
Journal of leukocyte biology - 24 Nov 2023
Vadillo Eduardo, Mantilla Alejandra, Aguilar-Flores Cristina, De León-Rodríguez Saraí Gisel, Vela-Patiño Sandra, Badillo Juan, Taniguchi-Ponciano Keiko, Marrero-Rodríguez Daniel, Ramírez Lourdes, León-Vega Iliana Itzel, Fuentes-Castañeda Carmen, Piña-Sánchez Patricia, Prieto-Chávez Jessica Lakshmi, Pérez-Kondelkova Vadim, Montesinos Juan José, Bonifaz Laura, Pelayo Rosana, Mayani Héctor, Schnoor Michael
Abstract excerpt
Neutrophils infiltrate several types of cancer; however, whether their presence is associated with disease progression remains controversial. Here, we show that colon tumors overexpress neutrophil chemoattractants compared to healthy tissues, leading to their recruitment to the invasive margin and the central part of colon tumors. Of note, tumor-associated neutrophils expressing tumor necrosis factor α, which...
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