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Article

Immunosuppressive low-density neutrophils in the blood of cancer patients display a mature phenotype.

Life science alliance - 1 Jan 2024

Vanhaver Christophe, Aboubakar Nana Frank, Delhez Nicolas, Luyckx Mathieu, Hirsch Thibault, Bayard Alexandre, Houbion Camille, Dauguet Nicolas, Brochier Alice, van der Bruggen Pierre, Bruger Annika M

Abstract excerpt

The presence of human neutrophils in the tumor microenvironment is strongly correlated to poor overall survival. Most previous studies have focused on the immunosuppressive capacities of low-density neutrophils (LDN), also referred to as granulocytic myeloid-derived suppressor cells, which are elevated in number in the blood of many cancer patients. We observed two types of LDN in the blood of lung cancer and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37931958
DOI: 10.26508/lsa.202302332
PMCID: PMC10628041

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