Article
Genome-wide association study of Buruli ulcer in rural Benin highlights role of two LncRNAs and the autophagy pathway.
Communications biology - 20 Apr 2020
Manry Jeremy, Vincent Quentin B, Johnson Christian, Chrabieh Maya, Lorenzo Lazaro, Theodorou Ioannis, Ardant Marie-Françoise, Marion Estelle, Chauty Annick, Marsollier Laurent, Abel Laurent, Alcaïs Alexandre
Abstract excerpt
Buruli ulcer, caused by Mycobacterium ulcerans and characterized by devastating necrotizing skin lesions, is the third mycobacterial disease worldwide. The role of host genetics in susceptibility to Buruli ulcer has long been suggested. We conduct the first genome-wide association study of Buruli ulcer on a sample of 1524 well characterized patients and controls from rural Benin. Two-stage analyses identify two...
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