Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms

Abstract excerpt

Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent, Mycobacterium ulcerans, produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed to M. ulcerans develop clinical disease, as surrounding macrophages may control the infection by bacterial killing at an early stage, while...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Infectious Diseases and Mycology
• Share to Mycobacterium research and diagnosis
• Share to Tuberculosis Research and Epidemiology