Article
Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance.
Cancer cell - 10 Jan 2022
Newell Felicity, Pires da Silva Ines, Johansson Peter A, Menzies Alexander M, Wilmott James S, Addala Venkateswar, Carlino Matteo S, Rizos Helen, Nones Katia, Edwards Jarem J, Lakis Vanessa, Kazakoff Stephen H, Mukhopadhyay Pamela, Ferguson Peter M, Leonard Conrad, Koufariotis Lambros T, Wood Scott, Blank Christian U, Thompson John F, Spillane Andrew J, Saw Robyn P M, Shannon Kerwin F, Pearson John V, Mann Graham J, Hayward Nicholas K, Scolyer Richard A, Waddell Nicola, Long Georgina V
Abstract excerpt
We concurrently examine the whole genome, transcriptome, methylome, and immune cell infiltrates in baseline tumors from 77 patients with advanced cutaneous melanoma treated with anti-PD-1 with or without anti-CTLA-4. We show that high tumor mutation burden (TMB), neoantigen load, expression of IFNγ-related genes, programmed death ligand expression, low PSMB8 methylation (therefore high expression), and T cells in...
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