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Say Cheese: Structure of the Cardiac Electrical Engine Is Captured.

Trends in biochemical sciences - 1 May 2020

Ghovanloo Mohammad-Reza, Ruben Peter C

Abstract excerpt

Voltage-gated sodium channel (Nav)1.5 is the predominantly expressed sodium channel in the myocardium. Mutations in the gene encoding Nav1.5 are associated with several types of cardiac arrhythmias. In their recent study, Jiang et al. provide a detailed structure of the rat Nav1.5, with major implications regarding its physiology, pharmacology, and pathophysiology.

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Identifiers

PMID: 32311330
DOI: 10.1016/j.tibs.2020.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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