Article
Association of Human Papillomavirus Type 16 Long Control Region Variations with Cervical Cancer in a Han Chinese Population.
International journal of medical sciences - 1 Jan 2020
Dai Shuying, Li Chuanyin, Yan Zhiling, Zhou Ziyun, Wang Xia, Wang Jun, Sun Le, Shi Li, Yao Yufeng
Abstract excerpt
Objective: High-risk human papillomavirus (HPV) E6 and E7 proteins are the major oncoproteins involved in the tumorigenesis of cervical cancer. The long control region (LCR) in HPV plays an important role in regulating the expression of the E6 and E7 oncogenes. In the current study, we investigated the association of HPV16 LCR variations with cervical cancer. Methods: A total of 139 HPV16-positive cervical cancer...
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