Article
Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China.
BMC cancer - 7 Oct 2013
Sun Zhengrong, Lu Zhitao, Liu Jianhua, Wang Guili, Zhou Weiqiang, Yang Lianxia, Liu Chao, Wang Bo, Ruan Qiang
Abstract excerpt
BACKGROUND: High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region(LCR)of HPV16 may alter the oncogenic potential of the virus. The aims of this study were to investigate the genetic variations of HPV16 E6 gene and LCR in isolates from Chinese population and correlation of the E6 and LCR...
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