Article
Update on canine filaggrin: a review.
The veterinary quarterly - 1 Dec 2020
Combarros Daniel, Cadiergues Marie-Christine, Simon Michel
Abstract excerpt
Human filaggrin (FLG) plays a key role in epidermal barrier function, and loss-of-function mutations of its gene are primarily responsible for the development of human atopic dermatitis (AD). FLG expression is also reduced in the epidermis of atopic patients, due to the transcriptional effect of Th2 type cytokines. Canine atopic dermatitis (CAD) is a prevalent skin disease that shares many clinical and pathogenic...
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