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Article

Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line.

Virology journal - 19 Apr 2020

Abdulsalam Ibrahim, Rasheed Kashif, Sveinbjørnsson Baldur, Ehlers Bernhard, Moens Ugo

Abstract excerpt

BACKGROUND: Merkel cell polyomavirus (MCPyV) is a human polyomavirus that establishes a life-long harmless infection in most individuals, with dermal fibroblasts believed to be the natural host cell. However, this virus is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. Several MCPyV variants with polymorphism in their promoter region have been isolated, but it is not known whether...

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Share to Antigens, Viral, Tumor
Share to Carcinoma, Merkel Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Fibroblasts

Share to Gene Expression Regulation, Viral

Share to Transcription, Genetic

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Source

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Identifiers

PMID: 32306957
DOI: 10.1186/s12985-020-01317-x
PMCID: PMC7168875

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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