Article
New Gene Variants Associated with the Risk of Chronic HBV Infection.
Virologica Sinica - 1 Aug 2020
Fan Mengjie, Wang Jing, Wang Sa, Li Tengyan, Pan Hong, Liu Hankui, Xu Huifang, Zhernakova Daria V, O'Brien Stephen J, Feng Zhenru, Chang Le, Dai Erhei, Lu Jianhua, Xi Hongli, Yu Yanyan, Zhang Jianguo, Wang Binbin, Zeng Zheng
Abstract excerpt
Some patients with chronic hepatitis B virus (HBV) infection failed to clear HBV, even persistently continue to produce antibodies to HBV. Here we performed a two stage genome wide association study in a cohort of Chinese patients designed to discover single nucleotide variants that associate with HBV infection and clearance of HBV. The first stage involved genome wide exome sequencing of 101 cases (HBsAg plus...
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