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Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

15 Apr 2020

Abstract excerpt

The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. We recently reported that HIV-1 Vif is also able to degrade the PPP2R5 family of regulatory subunits of key cellular phosphatase PP2A (PPP2R5A-E; Greenwood et al., 2016; Naamati et al., 2019). We now identify amino acid polymorphisms at...

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PMID: 32292164
DOI: 10.7554/elife.53036

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Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrestPMID 32292164Read ↗

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