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Article

Translational regulation of APOBEC3G mRNA by Vif requires its 5'UTR and contributes to restoring HIV-1 infectivity.

Scientific reports - 20 Dec 2016

Guerrero Santiago, Libre Camille, Batisse Julien, Mercenne Gaëlle, Richer Delphine, Laumond Géraldine, Decoville Thomas, Moog Christiane, Marquet Roland, Paillart Jean-Christophe

Abstract excerpt

The essential HIV-1 viral infectivity factor (Vif) allows productive infection of non-permissive cells expressing cytidine deaminases APOBEC3G (A3G) and A3F by decreasing their cellular level, and preventing their incorporation into virions. Unlike the Vif-induced degradation of A3G, the functional role of the inhibition of A3G translation by Vif remained unclear. Here, we show that two stem-loop structures...

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Share to 5' Untranslated Regions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytosine Deaminase

Share to Gene Expression Regulation, Viral

Share to HEK293 Cells

Share to Proteasome Endopeptidase Complex

Share to Protein Processing, Post-Translational

Share to vif Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 27996044
DOI: 10.1038/srep39507
PMCID: PMC5171582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Translational regulation of APOBEC3G mRNA by Vif requires its 5'UTR and contributes to restoring HIV-1 infectivity.PMID 27996044Read ↗

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