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Article

Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes.

Infection and immunity - 1 Jul 2008

Ivie Susan E, McClain Mark S, Torres Victor J, Algood Holly M Scott, Lacy D Borden, Yang Rong, Blanke Steven R, Cover Timothy L

Abstract excerpt

Helicobacter pylori VacA is a secreted pore-forming toxin that is comprised of two domains, designated p33 and p55. The p55 domain has an important role in the binding of VacA to eukaryotic cell surfaces. A total of 111 residues at the amino terminus of p55 (residues 312 to 422) are essential for the intracellular activity of VacA, which suggests that this region may constitute a subdomain with an activity...

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Identifiers

PMID: 18443094
DOI: 10.1128/IAI.01664-07
PMCID: PMC2446698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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