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Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples.

Addiction biology - 1 Mar 2021

Fan Rongli, Cui Wenyan, Chen Jiali, Ma Yunlong, Yang Zhongli, Payne Thomas J, Ma Jennie Z, Li Ming D

Abstract excerpt

Nicotine dependence (ND) is a chronic brain disorder that causes heavy social and economic burdens. Although many susceptibility genetic loci have been reported, they can explain only approximately 5%-10% of the genetic variance for the disease. To further explore the genetic etiology of ND, we genotyped 242 764 SNPs using an exome chip from both European-American (N = 1572) and African-American (N = 3371)...

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PMID: 32281736
DOI: 10.1111/adb.12898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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