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Article

Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.

Acta neuropathologica communications - 17 Dec 2013

Hoffmann Nadine A, Dorostkar Mario M, Blumenstock Sonja, Goedert Michel, Herms Jochen

Abstract excerpt

BACKGROUND: Illuminating the role of the microtubule-associated protein tau in neurodegenerative diseases is of increasing importance, supported by recent studies establishing novel functions of tau in synaptic signalling and cytoskeletal organization. In severe dementias like Alzheimer's disease (AD), synaptic failure and cognitive decline correlate best with the grade of tau-pathology. To address synaptic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24344647
DOI: 10.1186/2051-5960-1-82
PMCID: PMC3880070

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