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Compartmentalization and Clonal Amplification of HIV-1 in the Male Genital Tract Characterized Using Next-Generation Sequencing.

Journal of virology - 1 Jun 2020

Kariuki Samuel Mundia, Selhorst Philippe, Anthony Colin, Matten David, Abrahams Melissa-Rose, Martin Darren P, Ariën Kevin K, Rebe Kevin, Williamson Carolyn, Dorfman Jeffrey R

Abstract excerpt

Compartmentalization of HIV-1 between the systemic circulation and the male genital tract may have a substantial impact on which viruses are available for sexual transmission to new hosts. We studied compartmentalization and clonal amplification of HIV-1 populations between the blood and the genital tract from 10 antiretroviral-naive men using Illumina MiSeq with a PrimerID approach. We found evidence of some...

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Clone Cells
Genitalia, Male
High-Throughput Nucleotide Sequencing
HIV-1
HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

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PMID: 32269124
DOI: 10.1128/JVI.00229-20
PMCID: PMC7307092

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