Article
Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time.
The Journal of infectious diseases - 15 Apr 2013
Bull Marta E, Heath Laura M, McKernan-Mullin Jennifer L, Kraft Kelli M, Acevedo Luis, Hitti Jane E, Cohn Susan E, Tapia Kenneth A, Holte Sarah E, Dragavon Joan A, Coombs Robert W, Mullins James I, Frenkel Lisa M
Abstract excerpt
BACKGROUND: Whether unique human immunodeficiency type 1 (HIV) genotypes occur in the genital tract is important for vaccine development and management of drug resistant viruses. Multiple cross-sectional studies suggest HIV is compartmentalized within the female genital tract. We hypothesize that bursts of HIV replication and/or proliferation of infected cells captured in cross-sectional analyses drive...
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