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Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts

8 Apr 2020

Abstract excerpt

Reversing the developmental switch from fetal hemoglobin (HbF, α2γ2) to adult hemoglobin (HbA, α2β2) is an important therapeutic approach in sickle cell disease (SCD) and β-thalassemia. In healthy individuals, SCD patients, and patients treated with pharmacologic HbF inducers, HbF is present only in a subset of red blood cells known as F cells. Despite more than 50 years of observations, the cause for this...

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PMID: 32268371
DOI: 10.1182/blood.2020005058

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