Fetal and adult hemoglobin production during adult erythropoiesis: coordinate expression correlates with cell proliferation

Abstract excerpt

The design and evaluation of therapies for the sickle cell and beta-thalassemia syndromes rely on our understanding of hemoglobin accumulation during human erythropoiesis. Here we report direct measurements of hemoglobin composition and messenger RNA (mRNA) levels in cultured CD34(+) cells and correlate those measurements with studies of freshly obtained bone marrow samples. Hemoglobin levels in differentiating...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood groups and transfusion
• Share to Erythrocyte Function and Pathophysiology
• Share to Hemoglobinopathies and Related Disorders