Genome-scale analysis of the non-cultivable Treponema pallidum reveals extensive within-patient genetic variation.

Abstract excerpt

Insights into the genomic adaptive traits of Treponema pallidum, the causative bacterium of syphilis, have long been hampered due to the absence of in vitro culture models and the constraints associated with its propagation in rabbits. Here, we have bypassed the culture bottleneck by means of a targeted strategy never applied to uncultivable bacterial human pathogens to directly capture whole-genome T. pallidum...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Evolution, Molecular
• Share to Genetic Variation