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Article

RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation.

Journal of biological rhythms - 1 Feb 2020

Shakhmantsir Iryna, Dooley Scott J, Kishore Siddharth, Chen Dechun, Pierce Eric, Bennett Jean, Sehgal Amita

Abstract excerpt

Circadian clocks regulate multiple physiological processes in the eye, but their requirement for retinal health remains unclear. We previously showed that Drosophila homologs of spliceosome proteins implicated in human retinitis pigmentosa (RP), the most common genetically inherited cause of blindness, have a role in the brain circadian clock. In this study, we report circadian phenotypes in murine models of RP....

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Identifiers

PMID: 31726916
DOI: 10.1177/0748730419887876
PMCID: PMC7428848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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