Article
Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development.
Development (Cambridge, England) - 1 Aug 2009
Ng Anthony, Uribe Rosa A, Yieh Leah, Nuckels Richard, Gross Jeffrey M
Abstract excerpt
Although purines and purinergic signaling are crucial for numerous biochemical and cellular processes, their functions during vertebrate embryonic development have not been well characterized. We analyze two recessive zebrafish mutations that affect de novo purine synthesis, gart and paics. gart encodes phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole...
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