PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis

Abstract excerpt

The sensation of pain is essential for the preservation of the functional integrity of the body. However, the key molecular regulators necessary for the initiation of the development of pain-sensing neurons have remained largely unknown. Here, we report that, in mice, inactivation of the transcriptional regulator PRDM12, which is essential for pain perception in humans, results in a complete absence of the...

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