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Article

Somatic synonymous mutations in regulatory elements contribute to the genetic aetiology of melanoma.

BMC medical genomics - 3 Apr 2020

Zhang Di, Xia Junfeng

Abstract excerpt

BACKGROUND: Non-synonymous mutations altering tumor suppressor genes and oncogenes are widely studied. However, synonymous mutations, which do not alter the protein sequence, are rarely investigated in melanoma genome studies. METHODS: We explored the role of somatic synonymous mutations in melanoma samples from TCGA (The Cancer Genome Atlas). The pathogenic synonymous mutation and neutral synonymous mutation...

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Identifiers

PMID: 32241263
DOI: 10.1186/s12920-020-0685-2
PMCID: PMC7119296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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