Article
There is a world beyond protein mutations: the role of non-coding RNAs in melanomagenesis.
Experimental dermatology - 1 May 2013
Swoboda Rolf K, Herlyn Meenhard
Abstract excerpt
Until recently, the general perception has been that mutations in protein-coding genes are responsible for tumorigenesis. With the discovery of (V600E)BRAF in about 50% of cutaneous melanomas, there was an increased effort to find additional mutations. However, mutations characterized in melanoma to date cannot account for the development of all melanomas. With the discovery of microRNAs as important players in...
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