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Article

Insights into PPARγ Phosphorylation and Its Inhibition Mechanism.

Journal of medicinal chemistry - 14 May 2020

Montanari Roberta, Capelli Davide, Yamamoto Keiko, Awaishima Hirono, Nishikata Kimina, Barendregt Arjan, Heck Albert J R, Loiodice Fulvio, Altieri Fabio, Paiardini Alessandro, Grottesi Alessandro, Pirone Luciano, Pedone Emilia, Peiretti Franck, Brunel Jean Michel, Itoh Toshimasa, Pochetti Giorgio

Abstract excerpt

PPARγ represents a key target for the treatment of type 2 diabetes and metabolic syndrome. Synthetic antidiabetic drugs activating PPARγ are accompanied by serious undesirable side effects related to their agonism. In the search for new PPARγ regulators, inhibitors of PPARγ phosphorylation on S245 mediated by CDK5 represent an opportunity for the development of an improved generation of antidiabetic drugs acting...

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PMID: 32239932
DOI: 10.1021/acs.jmedchem.0c00048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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