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Article

Unveiling clinically significant PPARγ mutations for thiazolidinedione treatment responsiveness through atomistic simulations.

International journal of biological macromolecules - 31 Dec 2023

Shahrear Sazzad, Islam Abul Bashar Mir Md Khademul

Abstract excerpt

In Type 2 diabetes, increased insulin sensitivity is induced by thiazolidinedione activation of the peroxisome proliferator-activated receptor gamma (PPARγ). Recent data indicate a relationship between SNPs in PPARγ and poor drug response. Therefore, understanding the pathogenic consequences of mutations in PPARγ-mediated protein-drug interactions will be prima-facie for establishing personalized medicine. The...

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PMID: 37741483
DOI: 10.1016/j.ijbiomac.2023.126990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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