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Article

Tyrosine Hydroxylase Gene Polymorphisms Contribute to Opioid Dependence and Addiction by Affecting Promoter Region Function.

Neuromolecular medicine - 1 Sept 2020

Liu Jun-Lin, Li Shao-Qing, Zhu Feng, Zhang Yu-Xiang, Wu Ya-Nan, Yang Jing-Si, Zhang Bao, Yan Chun-Xia

Abstract excerpt

Mounting evidence shows that drug dependence involves the complex interplay between genetics and the environment. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine (DA) synthesis, which plays an essential role in the development of drug addiction. Noradrenergic dysfunction due to abnormalities TH expression has been implicated in the pathogenesis of drug addiction. We profiled...

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PMID: 32232669
DOI: 10.1007/s12017-020-08597-0

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