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Article

TPH1 and 5-HTTLPR Genes Specifically Interact in Opiate Dependence but Not in Alcohol Dependence.

European addiction research - 1 Jan 2016

Wang Tzu-Yun, Lee Sheng-Yu, Chung Yi-Lun, Chen Shiou-Lan, Li Chia-Ling, Chang Yun-Hsuan, Wang Liang-Jen, Chen Po See, Chen Shih-Heng, Chu Chun-Hsien, Huang San-Yuan, Tzeng Nian-Sheng, Hsieh Tsai-Hsin, Lee I Hui, Chen Kao Chin, Yang Yen Kuang, Hong Jau-Shyong, Lu Ru-Band

Abstract excerpt

BACKGROUND: Different drug dependencies may have unique genetic vulnerabilities. Changes in serotonin availability and function have been linked to addiction. We investigated whether 2 serotonergic polymorphisms, TPH1 A218C (rs1800532) and 5-HTT-linked promoter region (5-HTTLPR) (rs25531), are differently associated with alcohol or opiate dependence. METHODS: Alcohol-dependent patients (n = 292), opiate-dependent...

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Topics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Alcoholism
Share to Epistasis, Genetic
Share to Genetic Predisposition to Disease
Share to Genotype
Share to Opioid-Related Disorders
Share to Polymorphism, Single Nucleotide
Share to Serotonin Plasma Membrane Transport Proteins
Share to Tryptophan Hydroxylase

Source

Identifiers

PMID: 27045756
DOI: 10.1159/000444676

Genes

TPH1
HTT

Variants

rs1800532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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