Article
Lymphocyte activation gene 3 (LAG3) protein expression on tumor-infiltrating lymphocytes in aggressive and TP53-mutated salivary gland carcinomas.
Cancer immunology, immunotherapy : CII - 1 Jul 2020
Arolt Christoph, Meyer Moritz, Ruesseler Vanessa, Nachtsheim Lisa, Wuerdemann Nora, Dreyer Thomas, Gattenlöhner Stefan, Wittekindt Claus, Buettner Reinhard, Quaas Alexander, Klussmann Jens Peter
Abstract excerpt
Salivary gland carcinomas (SGCs) are rare and can be subdivided into distinct entities, some of which confer a poor prognosis. As targets for effective systemic therapy are warranted, some studies investigated the role of immune-checkpoint proteins PD-L1 and CTLA-4 in SGC. Our study depicts the expression of lymphocyte activation gene 3 (LAG3) in a test cohort and a larger validation cohort, totaling 139 SGCs....
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