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Article

A new algorithm to convert a normal antibody into the corresponding catalytic antibody.

Science advances - 1 Mar 2020

Hifumi Emi, Taguchi Hiroaki, Tsuda Haruna, Minagawa Tetsuro, Nonaka Tamami, Uda Taizo

Abstract excerpt

Over thousands of monoclonal antibodies (mAbs) have been produced so far, and it would be valuable if these mAbs could be directly converted into catalytic antibodies. We have designed a system to realize the above concept by deleting Pro95, a highly conserved residue in CDR-3 of the antibody light chain. The deletion of Pro95 is a key contributor to catalytic function of the light chain. The S35 and S38 light...

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Share to Amyloid beta-Peptides
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Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32232151
DOI: 10.1126/sciadv.aay6441
PMCID: PMC7096177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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