Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Site‐specific proteolytic degradation of IgG monoclonal antibodies expressed in tobacco plants

4 Oct 2014

Abstract excerpt

Plants are promising hosts for the production of monoclonal antibodies (mAbs). However, proteolytic degradation of antibodies produced both in stable transgenic plants and using transient expression systems is still a major issue for efficient high-yield recombinant protein accumulation. In this work, we have performed a detailed study of the degradation profiles of two human IgG1 mAbs produced in plants: an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Monoclonal and Polyclonal Antibodies Research
Share to Transgenic Plants and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25283551
DOI: 10.1111/pbi.12266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Site‐specific proteolytic degradation of IgG monoclonal antibodies expressed in tobacco plantsPMID 25283551Read ↗

Site-targeted mutagenesis for stabilization of recombinant monoclonal antibody expressed in tobacco (Nicotiana tabacum) plants.Semantic proximity Read ↗

Fragmentation of monoclonal antibodiesSemantic proximity Read ↗

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants.Semantic proximity Read ↗

Targeting dsRNA-specific single-chain Fv antibody fragments to different cellular locations in Nicotiana tabacum L.Semantic proximity Read ↗

Improved virus neutralization by plant-produced anti-HIV antibodies with a homogeneous beta1,4-galactosylated N-glycan profile.Semantic proximity Read ↗

Production systems for recombinant antibodiesSemantic proximity Read ↗

Fusion of an <scp>F</scp>c chain to a <scp>VHH</scp> boosts the accumulation levels in <i><scp>A</scp>rabidopsis</i> seedsSemantic proximity Read ↗

Engineered tobacco etch virus (TEV) protease active in the secretory pathway of mammalian cells.Semantic proximity Read ↗

Humanization and Expression of IgG and IgM Antibodies in Plants as Potential Diagnostic Reagents for Valley FeverSemantic proximity Read ↗

Biocomputational analysis to evaluate stacking dual-targeting antibodies in agricultural tobacco plantSemantic proximity Read ↗

Production and characterization of anti‐(mucin MUC1) single‐domain antibody in tobacco (<i>Nicotiana tabacum</i> cultivar Xanthi)Semantic proximity Read ↗

Expression and glycoengineering of functionally active heteromultimeric IgM in plantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.