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Article

Lamin Mutations Cause Increased YAP Nuclear Entry in Muscle Stem Cells.

Cells - 27 Mar 2020

Owens Daniel J, Fischer Martina, Jabre Saline, Moog Sophie, Mamchaoui Kamel, Butler-Browne Gillian, Coirault Catherine

Abstract excerpt

Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects in myonucleus integrity. We previously reported that L-CMD mutations compromise the ability of muscle stem cells to modulate the yes-associated protein (YAP), a pivotal factor in mechanotransduction...

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Share to Active Transport, Cell Nucleus
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32231000
DOI: 10.3390/cells9040816
PMCID: PMC7226749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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