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Article

Genetic Alterations in Medullary Thyroid Cancer: Diagnostic and Prognostic Markers

14 Nov 2011

Abstract excerpt

Medullary thyroid carcinoma (MTC) is a rare calcitonin producing neuroendocrine tumour that originates from the parafollicular C-cells of the thyroid gland. The RET proto-oncogene encodes the RET receptor tyrosine kinase, with consequently essential roles in cell survival, differentiation and proliferation. Somatic or germline mutations of the RET gene play an important role in this neoplasm in development of...

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PMID: 22654561
DOI: 10.2174/138920211798120835

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