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Article

Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma

6 Mar 2020

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) has been extensively researched over the last few decades, yet despite aggressive multimodal treatment, recurrence is inevitable and second-line treatment options are limited. Here, we demonstrate how high-throughput screening (HTS) in multicellular spheroids can generate physiologically relevant patient chemosensitivity data using patient-derived cells in a rapid and cost-effective...

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PMID: 32227096
DOI: 10.1093/neuonc/noaa051

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